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Laboratoire
Explore Genomes.
Decode Life.

Master 2 GenE2 – Genetics, Genomics, Epigenetics & Evolution

The GenE2 Master's programme trains future genome scientists by integrating genetics, genomics, epigenetics, evolution, bioinformatics, and high-throughput data analysis. The programme covers the structural, functional, and evolutionary aspects of genomes, from molecular mechanisms to population-level processes.

The curriculum combines a strong theoretical and practical background with hands-on exposure to state-of-the-art technologies used in modern research, including workshops in ChIP-seq, Big Data, single-cell omics, and bioinformatics.

Supported by leading French and international research laboratories, the programme addresses major topics such as DNA replication, repair and recombination, gene expression regulation, epigenomics, genomic variation, cancer genomics, non-coding RNAs, and genome evolution.

A key strength of the GenE2 programme is its integrative and multi-species approach, which connects molecular mechanisms, next-generation omics technologies, and data analysis to the study of evolution, adaptation, and biological diversity.

Key Strengths and Distinctive Features of the GenE2 Master's Program

  • A multidisciplinary training program, combining molecular biology, genetics and genomics with data analysis, computational biology, and bioinformatics.

  • A hands-on ChIP-seq workshop, allowing students to perform a complete chromatin immunoprecipitation followed by high-throughput Illumina sequencing experiment, from sample preparation and library preparation to sequencing and data analysis.

  • A Big Data workshop dedicated to the analysis of high-throughput sequencing datasets. This practical training familiarizes students with the processing, integration, visualization, and interpretation of complex datasets generated from genomics, epigenomics, transcriptomics, and other omics approaches.

  • A specialized training module in Non-coding RNAs and Epigenetics, covering the molecular mechanisms that regulate genome function, including chromatin organization, epigenetic regulation, RNA-mediated gene control, genome stability, development, and disease.

  • A dedicated training module in Single-Cell Omics and Spatial Transcriptomics, introducing students to the latest experimental and computational approaches used to investigate cellular heterogeneity, tissue organization, gene expression dynamics, and cell-to-cell interactions at single-cell resolution.

  • Courses taught entirely in English, including lectures and seminars delivered by leading researchers and experts in genetics, genomics, epigenetics, evolution, and systems biology.

  • Exposure to cutting-edge technologies, including next-generation sequencing (NGS), functional genomics, epigenomics, non-coding RNA biology, single-cell omics, spatial transcriptomics, multi-omics integration, artificial intelligence, and advanced bioinformatics methods.

  • A six-month research internship, carried out in an academic laboratory, research institute, hospital, or biotechnology company, either in France or abroad.

  • An extensive network of partner laboratories, located in the Paris-Saclay cluster, throughout France, and internationally, providing numerous opportunities for internships, collaborative projects, and PhD training.

  • A research-driven program, embedded within the outstanding scientific environment of Université Paris-Saclay, one of Europe's leading research-intensive universities, and benefiting from access to world-class research institutes, core facilities, and technological platforms.

Research-oriented training through research, combining advanced lectures, hands-on practical workshops, data analysis training, and a six-month research internship in an academic or industrial laboratory in France or abroad

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Certification cours innovant GS LSH Pari
A ChIP-seq workshop to design and perform a chromatin immunoprecipitation experiment.

Un atelier BigData pour l'analyse des données de séquençage à haut-débit

Une formation pratique unique en France !

  • De la conception d'une expérience de séquençage à l'acquisition des données à haut-débit par un atelier pratique ChIP-seq

  • Présentation des dernières technologies de séquençage 

  • Introduction à la manipulation de données à haut-débits

  • Analyse et traitement bioinformatique des données

  • Analyses biostatistiques des expériences 

Les débouchés
et insertion professionnelle
du Master GenE2

La thèse

Après l'obtention du diplôme de Master, les étudiants ont la possibilité de poursuivre en thèse via l'obtention d'un contrat doctoral proposé par une École Doctorale (ED de Paris-Saclay ou extérieure), de postuler à un programme 'PhD Track' en France ou à l'étranger ou via un fiancement propre du laboratoire d'accueil (SIFRE, ANR, ERC, ...)

Débouchés principaux

Recherche fondamentale ou appliquée en secteur académique (Paris-Saclay, ENS, Institut Pasteur, Institut Curie, Institut Jacques Monod, Genopole, ...) ou R&D en secteur privé, en France ou à l’étranger. Ingénieur d'études, ingénieur de recherche, analyste, ...

Domaines de recherche

Bio-informatique, analyse des données, cancérologie, thérapie génique, biotechnologies, écologie, environnement,  conseil génétique, enseignement, veille scientifique, communication scientifique, valorisation ...

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